Due to reduced blood flow, patients with diabetes are at risk of developing non-healing or infected wounds. These wounds (also known as diabetic ulcers) most commonly occur on the feet, and affect up to 34% of patients with diabetes during their lifetime . Diabetic wounds must be treated immediately to avoid infection that can lead to life threatening sepsis and/or amputation.
Cynata’s Cymerus™ mesenchymal stem cells (MSCs) were used in an independent study conducted by the Cooperative Research Centre for Cell Therapy Manufacturing (CTM CRC) in a preclinical model of diabetic wounds.
CTM CRC evaluated cells from five different sources: Cymerus MSCs, bone marrow-derived MSCs supplied by a commercial manufacturer, and MSCs derived from dental pulp, bone chips and gingival fibroblasts (cells found in the gums).
The primary outcome measure was the extent of re-epithelialisation (skin restoration) of the wound surface after three days, which is representative of the speed of wound healing.
These results suggest that the most effective cell types for this application are Cymerus MSCs or MSCs derived from gingival fibroblasts or bone chips. However, the gingival fibroblast- and bone chip derived MSCs were produced in an academic laboratory under non-GMP conditions, and there are major challenges associated with producing clinical-grade cells from those sources at commercial scale. Conversely, Cynata’s Cymerus technology platform provides a readily available and effectively limitless source of consistent, clinical-grade MSCs.
 Diabetes Australia